As the technology for medical radiotherapy and radiosurgery evolves, there is a growing need for dosimeters capable of measuring dose distributions on-line with submillimetre spatial resolution, both for facility commissioning and patient-related quality assurance.
As the technology for medical radiotherapy and radiosurgery evolves, there is a growing need for dosimeters capable of measuring dose distributions on-line with submillimeter spatial resolution, both for facility commissioning and patient-related quality assurance.
In the present study, we used an ultrasensitive assay for PCT, capable of measuring low levels to identify even "subclinical" inflammatory states before the development of clinically evident sepsis.
A TLDA was custom designed and ordered from Applied Biosystems, containing Gene Expression Assays capable of measuring mRNA for 94 breast cancer related genes (96 TaqMan® Gene Expression assay preconfigured in a 384-well format, Part no. 4342261, Lot No A3400, microfluidic cards; Applied Biosystems, Foster City, CA 94404).
For example, traps capable of measuring, or applying, femto-Newton scale forces with nanometric spatial resolution can be designed.
To test the prototype, we have developed new electronics for ∼300 pixels capable of measuring a single electron timing resolution to ∼100 ps.
Fluorescence correlation spectroscopy (FCS) is a powerful tool for biophysical research, capable of measuring concentrations, diffusion coefficients, and chemical and binding kinetics with single-molecule sensitivity [ 1, 2].
We have described the development of a high-throughput platform capable of measuring transcriptional dynamics for many genes in large numbers of single cells exposed to the same experimental conditions.
Even for physical techniques capable of measuring the distribution of products, such as chromatography, photobleaching, and mass spectrometry, characterization of conjugation distribution remains challenging in the presence of scaffold mass and structural dispersity.
For example, experiments capable of measuring folding events on a μs timescale (e.g. using ultra-rapid mixing [40]), or of detecting rare species (e.g. using FRET, fluorescence correlation spectroscopy (FCS) or NMR spectroscopy [24,41]) have revealed partially folded states populated during the folding of even the simplest proteins [42,43].
