However, all the advances of ribozymology notwithstanding, the prospects of a bona fide ribozyme replicase remain dim as the ribozymes designed for that purposes are capable, at best, of the addition of ~10 nucleotides to a oligonucleotide primer, at a very slow rate and with fidelity at least an order magnitude below that required for the replication of relatively long RNA molecules [ 28, 29].
If Sidiki's story is exceptional, the amazing thing is that it's not entirely out of the realm of what humans are capable at their best.
Not that Newcastle's manager has completely lost faith with a crowd favourite, capable at his best of lifting the team to a different level.
These items were followed by Mr. Copland's "A Lincoln Portrait," which, as most people know, represents the wide-open-spaces-cum-Americana Copland, rather than the atonal Copland we heard on opening night, and which is capable, at its best, of producing landscape backgrounds of a reasonably pleasing, if somewhat bleak, variety.
The data on organics had been largely obtained by using gas chromatography-mass spectrometry, which is only capable of analyzing, at best, 20% of the organics present in treated water.
Writing for the Boston Globe last week, the brilliant commentator HDS Greenway argued that even if America's military might were not already stretched thin, it would at best only be capable of delaying Iran's nuclear program for a few years.
In addition, Buridan drops his epistemological standards for sensory knowledge in general: because of the possibility of God's deceptiveness, at best we are capable of "conditional evidentness".
Commercially available force sensors based on piezoelectric devices or strain gauges are capable of measuring a few micronewtons at best [23].
Tyga is a labored rapper at best, though he's capable of a variety of cadences.
At best, a model will be capable of explaining all the available data and can be tested against some of its predictions.
A more recent meta-analysis [ 35] indicated that while the HBM was capable of predicting 10% of variance in behaviour at best, the included studies were heterogeneous and were unable to support conclusions as to the validity of the model.
