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Therefore, strategies aiming at re-establishing the cell's capability to activate a cell death program are an area of active research.
Notably, the Y416F mutant of vSrc-dsRed displayed a markedly reduced capability to activate STAT5A, which we attributed to the attenuated kinase activity that has been reported for this construct [ 22].
The additional benefit of the PDPCs over their analog counterpart is the capability to activate a single cell at a time; this reduces the tile active area but allows to monitor the signal and the noise in each cell.
Moreover, these results support the hypothesis that there are several active conformations of the TSHR, which differ in their capability to activate different downstream signaling cascades, as previously reported [19], [20], [21].
The luciferase reporter assay in Figure 2B showed that STAT3-dependent transcriptional activity was increased in cells expressing TRK oncogenes, indicating their capability to activate STAT3.
Main Results: Local return stimulation enhanced the capability to activate cells near the central electrode (<30 m) while avoiding cells farther away (>30 m).
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These included bids to extract personal information from data transmitted by apps including Angry Birds, as well as a range of capabilities to activate remotely the microphone on iPhones and Android devices – a project codenamed Nosey Smurf.
Just four states ― California, Florida, Michigan and Nevada ― plus the District of Columbia allow vehicles with limited self-driving capabilities to activate them on major highways.
These effects are due to the capability of AA to activate AMP-activated protein kinase mammalian target of rapamycin (mTOR) and nitric oxide synthase (NOS).
The present findings indicate that the capability to rapidly activate the quadriceps muscle group is an important factor accounting for inter-individual variability of walking speed among older men, but not among older women.
The level of property enhancements of ternary nanocomposites depends essentially on the microstructure inducing a volume exclusion effect and the capability of fillers to activate the plastic deformation mechanisms in the matrix.
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