In this study, we investigated the effect of hypoxia on the acquisition of stem cell-like properties such as early-differentiation markers, G1-arrest, quiescent phenotype, capability of tumor initiation in vivo and drug resistance in MM cells.
Cancer stem cells are generally identified by (i) the expression of common stem cell and early-differentiation markers, (ii) G1-arrest and quiescent phenotype, (iii) capability of fast tumor initiation, (iv) chemoresistance, (v) high expression of drug transporters and enzymes detoxifying drugs; and (vi) acquisition of the epithelial-to-mesenchymal transition (EMT -phenotype.
The adhesive layer is modeled by using the cohesive interface elements with the capability of simulating the damage initiation and evolution mechanisms of adhesives.
Based on the thermogravimetric analysis and high resolution transmission electron microscopy, AMBImI monomer has encapsulated the MWCNT Br probably through the π-π and cation-π interactions invalidating the initiation capability of MWCNT Br.
Furthermore, TAZ is required for and sufficient to maintain self-renewal and tumor initiation capability of breast cancer stem cells (Cordenonsi et al., 2011).
Since we have already known that TAZ is required for and sufficient to maintain self-renewal and tumor initiation capability of breast cancer stem cells (Cordenonsi et al., 2011), it's interesting to study whether TAZ-induced temozolomide resistance is related to TAZ's function in GSCs.
RFPA code has the capability of simulating the whole fracturing process of initiation, propagation and coalescence of fractures around excavations.
Moreover, the evolution of the strain profiles measured by DFOSs during the flexural tests clearly demonstrated the capability of DFOSs to detect crack initiation and propagation in CPM beams.
Employing advanced material such as carbon‐fibre‐reinforced‐polymer (CFRP) in tension fatigue strengthening of aged roads and railway bridges have shown a great capability of arresting or delaying crack initiation and/or propagation in steel structures.
The capability of shot peening to hinder the initiation and to retard the subsequent propagation of surface cracks is discussed on the basis of a model combining a multiaxial fatigue criterion and a fracture mechanics approach.
