To test whether the expression pattern in peripheral whole blood is representative for atherosclerosis in general, we have examined the capability of expression of genes derived from the peripheral blood cell study to predict the severity of atherosclerosis in human aortas.
This study has employed a candidate gene approach to further explore the potential predictive capability of expression of a previously reported treatment response gene, CD11c, using a clinically applicable sample source (as opposed to the original sample source of monocytes).
This study was designed to explore the capabilities of expression profiling technology to identify subtle differences in gene expression.
To optimize the full capability of gene expression profiling using microarray-based assays, technologies are being optimized to reliably perform gene expression profiling on FFPE specimens, currently the most common type of clinical specimen available, particularly for phase III adjuvant treatment trials.
The capability of gene expression microarrays to simultaneously measure essentially all human genes has made possible a variety of approaches to analyzing biological samples [10].
Unfortunately, the molecular mechanisms underlying the prognostic capabilities of ΔNp63 expression are unclear.
In this work, we have characterized VLPs using a number of established influenza assays aiming to better compare the production capabilities of two expression platforms.
Based on the older idea [ 8] that tumors and wounds produce a similar microenvironment which facilitates proliferation and migration of cells and stimulates angiogenesis, the papers of Chang and collaborators [ 9, 10] determined prognostic capabilities of gene expression signatures associated to wound healing.
This allows for the potential of "promoter bashing" experiments or including inducible control elements to further expand the capability of our siRNA expression cassette.
In extension of this, individual differences in the capability of suppressing the expression of the 38Ser variant might predispose 38Ser carriers more or less to LQTS.
