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These peptides were screened by ELIspot analysis for their capabilities to elicit interferon-gamma (IFN-γ) responses in the peripheral blood mononuclear cells (PBMCs), which were collected from pigs immunized with attenuated PRRSV HuN4-F112 strand and challenged with highly pathogenic HuN4 strain.
The cysLTs, LTC4, and their extracellular derivatives, LTD4 and LTE4, are recognized as paracrine mediators pertinent to asthma and allergic diseases based on their receptor-mediated capabilities to elicit bronchoconstriction, mucous hypersecretion, bronchial hyperresponsiveness, increased microvascular permeability, and additional eosinophil infiltration [ 1, 15, 18, 37].
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We argued that these two kinds of technical breakdowns reduce the capability of VR in supporting the intentions of the user and its capability to elicit emotive reactions.
Subsequently the immunogenicity of these mutations is defined, and finally, mutations are tested for their capability to elicit T-cell immunogenicity [ 22].
For example, changes in the classical excitability parameters (e.g., Rin, threshold) suggested increased excitability; whereas the capability to elicit high frequency firing is decreased.
However, the beneficial part of the live vaccines is the possibility of large-scale production, low cost, and, most importantly, their capability to elicit robust mucosal and cell-mediated immunity.
It is noteworthy that recent study showed a proof-of-concept in which somatic mutations are first detected using NGS, then the immunogenicity of these mutations is defined, and finally, mutations are tested for their capability to elicit T cell immunogenicity [ 15].
The presence of high numbers of cytotoxic T lymphocytes (CTLs) in the tumours of cancer patients correlates with enhanced survival 1– 3. Several murine models have shown the capability of cancer immunotherapy to elicit strong avidity T cell responses in vivo after vaccination.
Furthermore, the capability of the miniature coils to elicit a neuronal response in specific portions of the (peripheral) nerve will be investigated.
The capability of probe-level analysis to elicit novel findings from existing expression microarray data was demonstrated.
The capability of a cancer treatment to elicit Immunogenic Cell Death is clinically relevant since it is associated with an anticancer immune response that reinforces the therapeutic effect of the therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com