Therefore, strategies aiming at re-establishing the cell's capability to activate a cell death program are an area of active research.
Notably, the Y416F mutant of vSrc-dsRed displayed a markedly reduced capability to activate STAT5A, which we attributed to the attenuated kinase activity that has been reported for this construct [ 22].
The additional benefit of the PDPCs over their analog counterpart is the capability to activate a single cell at a time; this reduces the tile active area but allows to monitor the signal and the noise in each cell.
Moreover, these results support the hypothesis that there are several active conformations of the TSHR, which differ in their capability to activate different downstream signaling cascades, as previously reported [19], [20], [21].
The luciferase reporter assay in Figure 2B showed that STAT3-dependent transcriptional activity was increased in cells expressing TRK oncogenes, indicating their capability to activate STAT3.
Therefore, we fused dCpf1 with p300core and tested their capability to activate genes.
MicroRNA124a (miR-124a) has been considered as a neuronal lineage regulator, possessing the capability to activate neuronal differentiation.
Our study demonstrates that RBcs improves DCs' antigen presenting function and capability to activate T cells, and DC-based immunotherapy may be adopted in the treatment of RB.
An attenuated poxvirus, modified vaccinia Ankara (MVA) was selected to develop this vaccine strategy in Tx recipients, because of its clinical safety record, large foreign gene capacity, and capability to activate strong humoral and cellular immune responses against recombinant antigens.
Although all the processes enable to suppress the nitriding inhibition due to the presence of machining oil, ammonium chloride indicates the best capability to activate the adsorption of nitrogen of machining oil contaminated surfaces.
