To progress beyond a few millimetres, a cancer has to have the genetic potential and phenotypic capability of inducing the host breast tissue to supply a 'neovascularisation'. Historically this field has been reviewed by Gullino (1977) in ' The Natural History of Breast Cancer'; also more specifically and contemporaneously by Folkman (1995).
In mice, the dental epithelium prior to embryonic day 12 (E12) possesses odontogenic potential (tooth-inducing capability) and is capable of inducing tooth formation when confronted with mesenchymal tissue of non-dental origin [ 16].
This study presents the differentiation capability of induced pluripotent stem (iPS) cells in heparinized binary scaffolds composed of poly(ɛ-caprolactone) (PCL) and poly(β-hydroxybutyrate) (PHB).
In view of the rapidly advancing capabilities to induce events on the level of single atoms and molecules by scanning probe microscopy, it is anticipated that surface-supported magnetic molecules can be individually switched.
The characteristics of RRM2 to promote tumour progression are tightly associated with its capability to induce activities of a variety of oncogenes, including those encoding NF- κB, c-myc, v-fes and ornithine decarboxylase (Fan et al, 1998; Duxbury and Whang, 2007).
It is conceivable that the distinct responses of enhanced BRM expressing lines to zeocin and high-B treatments (Supplementary Fig. 10e) is attributed to their capability of inducing histone hyperacetylation.
Within the neural tube, at the level of the spinal cord, products of the vertebrate gene sonic hedgehog (shh) are proposed to function as a ventral patterning influence, with the capability of inducing floor plate and motor neurons.We report the isolation of tiggy-winkle hedgehog (twhh), a novel member of the zebrafish hh gene family.
Protein antigens present a quite promising alternative for vaccine development, due to the following characteristics: 1) absence of infectious materials like coding genes, 2) capability of inducing antigen-specific antibodies, 3) possibility for chemical modification and 4) the readiness for large scale manufacturing for a looming pandemic.
Cancer vaccine trials with these two antigens have demonstrated their capability of inducing humoral and cell-mediated immune responses in some patients, and examples of clinical responses have also been documented [7], [8], [9], [10].
Interestingly, data obtained by soft agar growth assay show that S75X, like p17Δ36, possesses the capability of inducing cell growth and malignant transformation of B cells, whereas the BH10-derived p17 shows an antiproliferative activity according to its Akt signalling pathway.
