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Importantly, the PSI – but not the CURB65 score – showed a high prognostic accuracy to predict adverse medical outcomes in patients with Legionella CAP in this study.
Diabetes, a classic risk factor for community-acquired K. pneumoniae infection, did not predispose patients to bacteremic K. pneumoniae CAP in this study.
Unfortunately about 8% of all drugs prescribed for children with CAP in this study could not be assessed due to non-existent information in the current guidelines for children aged 5 to 16 years.
While we did not validate the case definition of CAP in this study, we used pneumonia codes from similar previous studies [ 10, 14, 22, 23] and applied additional criteria to better identify CAP.
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As a result, overall adherence rates ranged from 58% to 132% (adherence measured by MEMS caps in this study was defined as the percentage of days with the medication container opened; adherence rate could be over 100% if the medication container was opened more than once a day) in the Internet-based intervention group and from 4%to80%0% the no-intervention group.
We established the direct ELISA to quantify the PCV2 Cap protein in this study.
21 23 As such we cannot exclude that overdiagnosis could have played a role in the increasing level of hospitalisation after CAP identified in this study.
The number of atypical/intracellular pathogens isolated from CAP patients in this study was small – in part due to the study design, which did not obtain convalescent serum in patients with initial cultures positive for typical pathogens and excluded patients with cultures positive for typical pathogens from the final analysis of atypical/intracellular pathogens.
The dose of moxifloxacin recommended for treatment of CAP in the study was 400 mg once every 24 hours, consistent with the local Summary of Product Characteristics.
Among inpatients with Pn-CAP, comorbidities as COPD (42.7% vs. 33.3%), diabetes mellitus (37.8% vs. 25.8%) and asthma (18.3% vs. 9.4%) were significantly (p<0.05) more frequent than among the remaining inpatients with CAP in the study, without differences in demographic data, treatments administered or in-hospital complications.
We divided the 323 CAPs investigated in this study into 38 protein families according to prior estimations of taxonomy and evolutionary relationships.
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