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The dose of moxifloxacin recommended for treatment of CAP in the study was 400 mg once every 24 hours, consistent with the local Summary of Product Characteristics.
Among inpatients with Pn-CAP, comorbidities as COPD (42.7% vs. 33.3%), diabetes mellitus (37.8% vs. 25.8%) and asthma (18.3% vs. 9.4%) were significantly (p<0.05) more frequent than among the remaining inpatients with CAP in the study, without differences in demographic data, treatments administered or in-hospital complications.
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CAP participated in the study conception and design.
CAP participated in the study design, data analysis, and helped draft the manuscript.
The lower leucocyte count of patients with K. pneumoniae bacteremic CAP in the present study is consistent with these findings.
While we did not validate the case definition of CAP in this study, we used pneumonia codes from similar previous studies [ 10, 14, 22, 23] and applied additional criteria to better identify CAP.
Unfortunately about 8% of all drugs prescribed for children with CAP in this study could not be assessed due to non-existent information in the current guidelines for children aged 5 to 16 years.
Importantly, the PSI – but not the CURB65 score – showed a high prognostic accuracy to predict adverse medical outcomes in patients with Legionella CAP in this study.
Demographic and clinical characteristics of CAP patients included in the study are shown in Table E2 in Additional File 1.
Thirty-three patients with confirmed CAP were included in the study; three were excluded (one was pregnant and two because of problems with their blood sample).
Male or female patients aged 18 years and above who were hospitalized with a diagnosis of CAP were included in the study after the decision to prescribe moxifloxacin was made by treating physicians.
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