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These observations indicate that exposure to CAP results in a rapid, specific, and reversible decrease in circulating EPC levels at low cumulative doses of CAP exposure.
However, sensitization with OVA before CAP exposure increased DA levels significantly (6.58 ± 2.8) compared with those of the control and the CAPs + saline group (p < 0.05).
CONCLUSIONS: Coarse CAP exposure produces a mild physiologic response in healthy young volunteers approximately 20 hr postexposure.
RESULTS: Compared with filtered air exposure, coarse CAP exposure produced a small increase in polymorphonuclear neutrophils in the bronchoalveolar lavage fluid 20 hr postexposure, indicating mild pulmonary inflammation.
CAP exposure.
CAP exposure suppresses VEGF signaling.
CAP exposure increases resident EPCs in bone marrow.
CAP exposure decreases the levels of circulating EPC.
CAP exposure does not induce EPC death or tissue deposition.
CAP exposure most affected HR between 0130 and 0430 hr.
The mechanism by which CAP exposure leads to changes in neurotransmitters in the brain is unclear.
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