Sentence examples for canonical role from inspiring English sources

They divert aminoacylated tRNAs from their canonical role in ribosomal protein synthesis, for cyclodipeptide formation.

And then it was one canonical role after another: "Mourning Becomes Electra" and "The Coast of Utopia" at the National, "Hedda Gabler" at the Almeida and "Moon" at the Old Vic.

In contrast to this canonical role, our earlier in vitro studies on the PHD1 domain have uncovered a function of the PHD1 domain in the allosteric regulation of the demethylase activity of KDM5A40.

This holds especially true for proteins or protein complexes such as the APC/C that are essential for proliferation, but fulfill beyond this canonical role additional crucial functions, i.e., during development or in quiescent and post-mitotic cells25,26,27.

In addition to its canonical role in crista membrane structure, MIC60 regulates mitochondrial motility, likely by influencing protein levels of the outer mitochondrial membrane protein Miro that anchors mitochondria to the microtubule motors.

The particular modification allows BMAL1 to work as a translation factor in a timely manner with response to the mTOR signaling, in addition to the canonical role in circadian transcription (Lipton et al., 2015).

The canonical function of kinases is to transfer a phosphoryl group to substrates, initiating a signaling cascade; while their non-canonical role is to bind other kinases or substrates, acting as scaffolds, competitors, and signal integrators.

Our results provide evidence for a previously unappreciated, non-canonical role for box C/D snoRNAs as regulators of metabolic stress response pathways in mammalian cells.

Aquaporin-1 (AQP1) channels are expressed by trabecular meshwork (TM) and Schlemm's canal cells of the conventional outflow pathway where fluid movement is predominantly paracellular, suggesting a non-canonical role for AQP1.

Based on the data, we propose a non-canonical role for ATM in supporting pro-tumorigenic behavior of cancer cells.

A non-canonical role has recently been observed, whereby the cohesin complex also represents a key regulator of gene expression.