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This growth enhancement depends on mTORC1's canonical function in controlling translation rate: mTOR inhibition slows translation, thereby matching protein synthesis to the limited amino acid supply.
The canonical function of kinases is to transfer a phosphoryl group to substrates, initiating a signaling cascade; while their non-canonical role is to bind other kinases or substrates, acting as scaffolds, competitors, and signal integrators.
The canonical function has the form (3.22).
There exist surely such a regularized factor and a canonical function of PH problem (4.37).
Since the boundary value of the canonical function from the upper half-plane on (2.24).
Canonical correlation analysis demonstrated positive and direct relationship in the first canonical function indicating that the nine mental health problems and various stressors were related (Canonical correlation = 0.715).
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Lane, S. I. R. & Jones, K. T. Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes.
Besides non-canonical function of caspases, other members of the mitochondrial pathway are also involved in non-death processes in cells.
An important question that arises from our current data is the nature of the mechanism that underlies this non-canonical function of zTERT.
The notion that Ubr2 plays a non-canonical function in protein turnover is further supported by the study of RECQL4 [22].
Given our findings of lengthening-independent and TR-binding domain-unrelated TERT function(s), hematopoiesis in zebrafish might be more susceptible to the disruption of a non-canonical function of TERT in comparison with the mouse.
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