Sentence examples for canonical checkpoint from inspiring English sources

Immunoblot and comet assays were performed to detect DNA breaks and activation of the canonical checkpoint signalling kinases following NEU damage upto 2 hours.

This can be explained, at least in part, by a requirement for Mps1 for Bub1 association with the kinetochore, allowing, in turn, canonical checkpoint activation and presumably Sgo1 and Ipl1 recruitment to centromeres (Fernius and Hardwick 2007; Storchová et al. 2011; London et al. 2012).

However, the 9 1 1 complex together with the Exo1 nuclease also participates in the error-free branch of the DNA damage tolerance pathway where it promotes template switching in a manner that is distinct from its canonical checkpoint functions and uncoupled from the replication fork.

Meiotic cells detect replication stress using the canonical replication checkpoint machinery, which then regulates meiosis-specific processes.

Similarly, the EBV EBNA3 proteins are capable of inhibiting the canonical G2/M checkpoint through suppression of p27 levels or activity depending on the cell type (Parker et al, 2000; Wade and Allday, 2000; Knight and Robertson, 2004).

Genes associated with the 'complement system' showed increased mRNA expression levels, whereas the canonical pathway 'G1/S checkpoint regulation' was found to be decreased in LP offspring.

An important consequence of gene deregulation through RB loss is the propensity to facilitate bypass of the canonical DNA damage checkpoints that inhibit G1 and S-phase progression [15], [16].

The "G2/M DNA damage checkpoint regulation" canonical pathway ranks the No. 1 most significant pathway found among CB-EPC genes.

Leukaemic CD34+CD38- cells tend to be dormant [ 4, 30], and despite its canonical role as a checkpoint kinase, chk2 is known to respond to damage in dormant cells [ 37].

Lane, S. I. R. & Jones, K. T. Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes.

In the case of LNCaP prostatospheres and DNA repair mechanisms, IPA reports that the role of CHK proteins in cell cycle checkpoint control is a top canonical pathway (Fig.  4a).