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However, reintroduction of FRNK under these circumstances (Fig. 4) inhibits these processes, suggesting that this is indeed a physical and repressive function of FAK mediated via FAT domain interactions (proliferation and migration are not inhibited by a mutant which cannot target to the Focal adhesion).
Similar(59)
β-arrestin1 S412D mutant cannot target receptors to clathrin-coated pits, thus disturbs β-arrestin1 mediated receptor endocytosis.
LRR domains carrying the 3020insC did not induce similar perturbations to the cellular metabolite profile suggesting proteins with Crohn's-associated mutations cannot target bacterial metabolism due to their lack of direct binding to the bacteria (Figure 1).
Therefore screening cannot be targeted to a specific genotype.
Indeed, available and emerging therapies to prevent obesity cannot be targeted to those high-risk individuals who likely would benefit the most.
These probes suffer from a number of limitations: (i) they lack specificity for a particular ROS; (ii) they cannot be targeted to specific intracellular compartments; and (iii) they can produce ROS upon light exposure and can therefore lead to false positives.
Public sector CIOs cannot target the right service areas to address without good business intelligence, which in itself requires good information that can be easily located – and that is no easy task.
Currently, you cannot target people who check-in to your Place, but a business can target people who 'Like' your Place page if you have performed a Page to Place merge.
It's important to understand that no matter what magazines try to tell you, you cannot target fat anywhere on your body by choosing particular exercises.
"What I can say unequivocally is that if you are a U.S. person, the NSA cannot listen to your telephone calls, and the NSA cannot target your emails … and have not," Obama said, according to a transcript provided by PBS.
The law explicitly says that CSE cannot target Canadians, and it must take steps to ensure that Canadians' privacy is respected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com