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It is noted that mathematical models cannot be validated with respect to the allowable value of predictors.
Due to the complexity of the hydrologic system and numerous data and modeling-related uncertainties, the above hypothesis cannot be validated with certainty.
The subjective pattern of response, i.e. in the subjective report on guideline utilization, cannot be validated with the present data.
Due to their intrinsic lack of kinetic information, these models cannot be validated with respect to their output and reside in the noncurated branch.
However, this approach has its limitations because separate genes cannot be validated with a gold standard, nor can they be excluded, as there are genes in this set that are similarly differentially expressed between MSCs in vivo vs both osteoblastomas and osteosarcomas.
Use of RNAi libraries for genome-wide screens is complicated by the presence of RNAi sequences that either do not result in efficient depletion, have off-target effects, or that cannot be validated with siRNAs targeting different sequences of the same gene.
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Another restriction of our approach is that it cannot be validated for genes with mutation in a few patients only (low mutation prevalence below 1%%).
It plays an important role in helping make informed decisions even when there is inadequate or incomplete information because it provides a framework to process available information with minimal reliance on assumptions that cannot be validated.
Unfortunately, with the current data this assumption cannot be validated or falsified.
As these assumptions cannot be validated, we supplemented the analyses by sensitivity analyses based on scenarios with realistic deviations from MAR.
However, due to the low efficiency of wireless transmission, the technology cannot be validated.
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