Our interpretation of these results is that the sperm defect is due to germline loss of mir-35, and thus cannot be rescued by nEx1187 because expression from high-copy extrachromosomal arrays is silenced in the germline (Kelly et al. 1997); however, other interpretations for the failure of nEx1187 to rescue the sperm defect are also possible.
They begin on an observation mission, investigating a primitive tribe on a jungly planet, but a desperate situation develops from which Spock cannot be rescued without infringing those Starfleet rules for which he is such a stickler.
Moreover, the hydroxylase activity of D414A P4H cannot be rescued with small molecules.
Preliminary data from our laboratory demonstrates that Ncad may genetically interact with other Rac GEFs to affect earlier CNS development Ncad mutants cannot be rescued by expression of RacWT alone in the CNS (Biersmith, B. and Geisbrecht, E.; unpublished data).
Mutant seedlings respond but cannot be rescued by BRs nor can the mutants be rescued by bulk sterols [ 59, 60].
Interestingly, the Sp substitution also interrupts cleavage but cannot be rescued with thiophilic metals.
This cannot be rescued by adding the dopamine agonist pergolide (Reimer et al., 2013).
RIPK3 ablation in Casp8 −/− gut safeguards these tissues from the inflammation observed with Casp8 deletion alone, but FLIP deletion cannot be rescued by simultaneous RIPK3 deletion, implying that the cell death in FLIP −/− gut is most likely apoptotic, not necroptotic.
Tethering PP1 directly to an Spc105 variant that cannot bind PP1 (Spc105RVSF-RASA) rescell celethalityity but, in contrast, tethering PP1 to wild-type Spc105 is lethal and cannot be rescued by disruption of the SAC (Rosenberg et al. 2011).
