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Many hepatotoxic responses are caused or exacerbated by corresponding immune system activation and released paracrine factors, which cannot be mimicked in simple monocultures of hepatocytes.
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Tissue tropism cannot be mimicked in vitro because EHEC is neither species- nor cell-type-specific in culture.
This allows for communication between different cell types implemented in degenerative joint diseases that cannot be mimicked in other in vitro models, such as cartilage explants.
Second, factors such as food seeking necessity, acute stress response or other general stressors associated with survival cannot be mimicked in the laboratory environment.
These events cannot be mimicked satisfactorily in in vitro.
Furthermore, the strong reduction in OLs and OPCs observed in long-standing human cortical MS lesions cannot be mimicked by recurrent demyelinating events in our experimental model.
They forget that we are complex beings whose thought patterns cannot be mimicked by a machine (at least not now nor in the near future).
In contrast to isotropic morphologies of synthetic hydrogels, many biological tissues possess anisotropic hierarchical morphologies leading to extraordinary mechanical properties that cannot be mimicked by synthetic materials.
The philosophy, like those in the #BreastIsBest corner of Instagram, stresses the bonding between mother and child that takes place through breastfeeding ― something that they imply cannot be mimicked through bottle feeding and formula.
However, such a cellular proximity feature cannot be easily mimicked in in vitro assay approaches.
"This balanced natural combination of phytochemicals present in fruits and vegetables cannot simply be mimicked by dietary supplements," he explained.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com