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The Pharmaceutical Research and Manufacturers Association says the companies are just complying with the F.D.A.'s requirement that they reveal all of a drug's risks, "even if a clear causal connection between the medicine and the observed adverse event cannot be fully established," a spokesperson for the group wrote in an e-mail.
Of course, the validity of a model cannot be fully established by application to empirical data whose underlying mechanisms or "ground truth" are never known with certainty.
Because randomisation is absent even if these threats to internal validity are assessed, causation still cannot be fully established.
However, the complex relationship between PRPs and listing cannot be fully established with these data, and further research is encouraged.
First, although our data support the notion that IR is an important factor in the pathogenesis of LV dysfunction in patients with AVS, causality cannot be fully established because this is a cross-sectional study.
In this sense, zebrafish is an important tool to analyze in vivo the molecular mechanisms related to the neurobiology of drug addiction, withdrawal and reward [ 31, 37– 39] that cannot be fully established in other animals models.
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Furthermore, the direction of causality cannot always be fully established, and it is possible that in some regions the diagnosed biases are unrelated.
What this truly means is yet to be fully established.
We do not know who her mother was: her ethnic inheritance can't be fully established.
Expected to be fully established by end of 2015.
Protection from diabetes after B 9-23/IFA immunisation cannot be achieved once diabetes is fully established, but can be achieved at most prediabetic stages of the disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com