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The reality is that the exponential combinations of patients, conditions and treatments cannot be exhaustively explored by processes that often intentionally or inadvertently exclude interdependent input/output parameters because they do not fit into a priori hypotheses or predefined models (Additional file 1: Figure S1).
The number of possible SNP combinations that have to be checked to find the minimal number of SNPs differentiating each taxon from every other by at least, say, four SNPs, well exceeds 10 and hence cannot be exhaustively explored.
The reality is that the exponential combinations of patients, conditions and treatments cannot be exhaustively explored by RCTs due to the large cost of adding even small numbers of patients.
Similar(57)
The polyelectrolyte effect of these materials was exhaustively explored through the acid-base properties, swelling and zeta potential.
However, these methods have some important caveats: treatment with harsh chemicals that affect properties of DNA or functions of DNA replicating machine tend to select for mutants (although this effect has not been exhaustively explored).
In order to obtain the transition probabilities among the different attractors (i.e., the entries of the so-called Markov matrix, see the detailed description below), the possible initial configurations of the system were exhaustively explored.
The diversity of this species has not been exhaustively explored yet, as previous efforts have focused on analyses of serotypes primarily implicated in human listeriosis.
In order to select the enzymatic numbers and their corresponding enzymes belonging to nucleotide metabolism, the KEGG [ 2] and MetaCyc [ 69] databases were exhaustively explored.
For the original SAX method, the two control parameters were exhaustively explored and all combinations of alphabet size and segment length were tried (a = [ 3- 8], w = [ 5, 10, 15, 20, 30]).
The Cameron government is said to have been exhaustively exploring all its options, including invoking an obscure mechanism from the 1960s citing "vital national interests" to automatically halt a decision at a summit, a move that looks legally dubious.
Yet, complex systems, like biological ones, cannot be exhaustively analysed because their evolution is not predictable.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com