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During oncogenic transformation, the mutated RAS is constitutively activated and cannot be deactivated by the GAP proteins [ 65].
This is because a constitutively active B-Raf cannot be deactivated by its phosphatase and there is no negative feedback loop within the B-Raf/MEK/ERK module to terminate or hinder the signal.
This is because a constitutively active Ras, which cannot be deactivated by Ras-GAP, is always able to activate Raf-1 and B-Raf which results in the constitutive activation of MEK and subsequently ERK to high levels.
Dogs do not fail during power outages, cannot be deactivated by experienced crooks, generally provide advanced warning of thieves, and don't have a 10 minute response time.
Similar(56)
Unlike myofibroblasts, CAFs are not removed by apoptosis and cannot be "deactivated".
The PCell cannot be deactivated, whereas each SCell can be switched on and off dynamically using MAC control element.
But, if there is a change in soil properties between two sides of the buried target, the DWS cannot be deactivated.
In case that unhygienic meat is used to produce heat processed products, the microorganisms will be deactivated by heat, so that they cannot be detected by a standard cultivation method.
In the relationships a node can be deactivated by multiple parents and a deactivation can likewise deactivate multiple children.
Smart guns feature locks that can only be deactivated by authorized users.
Deactivated nodes can be deactivated by multiple parents.
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