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A person in a coma cannot be aroused and is considered unconscious.
Sedation and analgesia consisted of midazolam and morphine, which were adjusted to obtain deep sedation (e.g. severe depression of consciousness during which patients cannot be aroused with repeated or painful stimulation); cisatracurium was administered to control shivering in the induction phase (bolus of 0.15 mg/kg) and then given, if needed, by continuous infusion (1 3 mcg/kg/min).
Rabbits were monitored twice daily to identify moribund animals (defined as those that are immobile, cannot be aroused to move from a recumbent position, and unable to access food or water) and those that have lost more than 15% of baseline weight, which are conditions stipulated by the UCSF committee on animal research for immediate euthanization.
In propofol anesthesia-induced unconsciousness and some DOC states, where patients cannot be aroused by external stimuli, both cortico-cortical and thalamo-cortical functional connectivity are disrupted (Boveroux et al., 2010).
It is a simple observational instrument assessing levels of sedation and agitation that requires no patient input [ 8] with scores ranging from +4 (representing an overtly combative patient) to -5, representing a patient who cannot be aroused by either voice or physical stimulation.
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Deep sedation patient cannot be easily aroused, but responds purposefully to repeated painful stimuli; may require assistance in maintaining airway and spontaneous ventilation.
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