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The genes that we identified by surrogate SNPs are candidates that require additional confirmation in independent samples.
We recognize that sequence homology and expression data can only identify possible candidates that require further experimental verification.
Since our pipeline includes several steps of manual tree inspection, we included several filters designed to reduce the number of candidates that require manual inspection and to limit them to those with the highest sequence similarity.
The product range for recombinant biopharmaceuticals includes relatively simple proteins, for example insulin, and ends with candidates that require extensive secondary modification like erythropoietin or coagulation factor IX [ 1, 2].
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Based on our results, PM is an obvious candidate that requires further reduction, whereas dioxins and formaldehyde seem to be less relevant from a population-wide EBD perspective.
Although only one locus, AT4G16280, remains statistically significant after controlling for multiple tests, several of these loci deserve special attention, and all of them should be considered candidate genes that require further examination in the future.
In the last two years, 11 published genome-wide association studies (GWASs) in AD confirmed the universally accepted role of APOE as a genetic risk factor for late-onset AD as well as generating additional candidate genes that require confirmation.
The results presented here represent and confirm the importance of SSC8 in reproductive traits in pig together with other regions in the genome and identify possible candidate genes that require further investigation.
Our results confirm previous findings suggesting that altered miRNA expression contributes to cancerous growth in the pancreas and provide new candidate miRNA genes that require validation in larger sample sets of normal and cancerous pancreatic tissues.
These genes are potentially interesting candidates that would require careful investigation to determine whether their expression changes have biological relevance.
Four other states -- Arizona, Maine, Massachusetts and Vermont -- have systems that require candidates who choose to receive public funds to refuse private donations.
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