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All investigators participated in determining the eligibility of candidate trials.
Using these criteria, 141 candidate trials were identified by abstract.
After obtaining full reports of the candidate trials the same reviewers independently assessed eligibility from full text papers.
Candidate trials must have compared albumin administration with crystalloid, no albumin or a lower dosage of albumin.
After initial screening and a subsequent more detailed evaluation of retrieved randomized trial reports, 32 candidate trials were identified.
After obtaining full reports of the candidate trials, in full peer-reviewed publication, the same reviewers independently assessed eligibility from full text papers.
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A null space approach is established to yield appropriate trial and test functions by using candidate trial functions which are free from boundary conditions.
The approach is applicable, with considerably mild conditions on the candidate trial functions, on the interior domain as well as its boundaries.
In this manner, one can determine all possible outcomes under candidate trial designs, allowing such trial designs to be compared in a strictly quantitative manner.
At key stages in the drug-development program, decision makers rely on the best rationale to select targets, drug candidates, trial designs, dose regimens, patient populations, and suitable end point measures.
However, multivalent DENV candidate vaccine trials have been severely hampered by difficulties in inducing a balanced serotype-specific immune responses in vaccinees [37].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com