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A null space approach is established to yield appropriate trial and test functions by using candidate trial functions which are free from boundary conditions.
The approach is applicable, with considerably mild conditions on the candidate trial functions, on the interior domain as well as its boundaries.
In this manner, one can determine all possible outcomes under candidate trial designs, allowing such trial designs to be compared in a strictly quantitative manner.
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All investigators participated in determining the eligibility of candidate trials.
Using these criteria, 141 candidate trials were identified by abstract.
After initial screening and a subsequent more detailed evaluation of retrieved randomized trial reports, 32 candidate trials were identified.
After obtaining full reports of the candidate trials the same reviewers independently assessed eligibility from full text papers.
Candidate trials must have compared albumin administration with crystalloid, no albumin or a lower dosage of albumin.
After obtaining full reports of the candidate trials, in full peer-reviewed publication, the same reviewers independently assessed eligibility from full text papers.
Our ES algorithm might predict candidate trials for a patient that the patient was truly eligible for, based on his/her clinical information, but because of the patient's preference the physician did not enroll the patient in that trial.
At key stages in the drug-development program, decision makers rely on the best rationale to select targets, drug candidates, trial designs, dose regimens, patient populations, and suitable end point measures.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com