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Moving beyond enumeration, molecular analysis of CEpCs may provide candidate surrogate endpoints to diagnose, treat, and monitor malignancy directly from the blood samples.
DFS and PFS have been ones of the preferred candidate surrogate endpoints, whatever cancer site.
Table 3 shows the association between healing and candidate surrogate variables with some baseline influencing factors.
Therefore, we speculate that PFS rate at 2 years could be another candidate surrogate for cure.
The area under the receiver operating characteristic (ROC) curve was calculated (20) for each candidate surrogate variable to evaluate its capacity and quality of discrimination among individuals.
Therefore, TNC seems to be an eligible candidate surrogate marker of ongoing tissue damage and may reflect disease activity or an impending flare.
Similar(29)
There are, of course, candidate surrogates: Gov. Janet Napolitano, Democrat of Arizona, for Mr. Obama and Senator Evan Bayh, Democrat of Indiana, for Mrs. Clinton.
As each of these candidate surrogates attests, the three finalists have produced stellar seasons and would be worthy recipients of the most prestigious award in college football.
With the area change dependent candidate surrogates, the estimation was only possible for log healing rate.
In the second questionnaire, they had to classify the previously proposed candidate surrogates from the most (position #1) to the least relevant in their opinion.
To quantify the contribution of the candidate surrogates to the final outcome, the product coefficient (PC) was estimated (21, 22), considering these variables as continuous.
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