Sentence examples for candidate mediator from inspiring English sources
The precondition for mediation is that the candidate mediator variable is associated with both the predictor and the outcome variables [41].
While HAF and HSP70 were not regulated by Notch1 ICD (data not shown), we found that CHIP, which encodes a ubiquitin ligase involved in HIF1a degradation, was moderately upregulated by Jagged1 immobilized ligand stimulation and strongly reduced by DAPT (Supplementary Figure 3A), making it a candidate mediator between Notch and HIF1α regulation.
NPY should be considered a candidate mediator of cephalic phase secretion.
While these data highlight miR-206 as a candidate mediator of impaired alveolarization associated with BPD, a causal role remains to be established.
Thus, while notch is a candidate mediator of microglia regulation by PS2, it is only one of several possible substrates.
In light of the increasingly recognized role of innate immunity in the progressive phase of MS pathogenesis [38], vitamin D-binding protein appears an interesting candidate mediator.
The other five transcription factor genes exhibited significantly increased expression in response to CH. Esrrb, Klf2, Nanog, Nr0b1, and Tcfcp2l1 thus emerge as candidate mediators of Gsk3/Tcf3-mediated ESC self-renewal.
The ever-growing number of candidate mediators for cell culture medium-mediated bystander effects were identified, among them transforming growth factor-β (TGF- β) [7], tumor necrosis factor-α (TNF- α) [8], interleukin-6 (IL-6) [9], interleukin-8 (IL-8) [10], reactive oxygen species (ROS) [11], and reactive nitrogen species [12].
The transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation.
Our genomic and biochemical analyses identified candidate mediators of primed state-specific Oct4 binding, including Otx2 and Zic2/3.
Third, the computational results that nicely reproduce the trend in reactivity between the investigated mediators and between the reduced and oxidized states suggest that computational screening will be a very effective tool to preselect candidate mediators.
