However, melanoma is known to be highly immunogenic and is therefore an attractive candidate indication for immunotherapy [5].
To evaluate the correctness of the candidate indication, the ith order prediction accuracy was calculated by (6) ACC i = P D i N, i = 1, 2, …, 56, where N denoted the total number of samples, while PD i denoted the number of samples whose ith order prediction is correct.
For each time, the prediction accuracies generally followed a descending trend with the increase of the order number, indicating that the candidate indications of the samples in DS(i ) were sorted quite well.
Similarly, the prediction accuracies always followed a descending trend with the increase of prediction order for each time, indicating that the method based on chemical similarities also arranged the candidate indications of the samples in DS(s ) quite well.
Statistical analysis is performed by comparing inferred candidate indications with the answer indication set.
Also, given a query drug, the method will provide a series of candidate indications.
As described in Section 2.2, the query drug was assigned a series of candidate indications, ranging from the most likely one to the least one.
Because it is a multilabel classification problem where a drug may possess more than one indication, our method provided a series of candidate indications for any query drug, ranging from the most likely one to the least likely one.
An important merit of the method is that, given a query drug, it can provide a series of candidate indications, ranging from the most likely one to the least likely one.
Although the study will identify candidate indications for systematic review for evidence of validity and reliability, the quality of the included studies will not be assessed in this study given its scoping design.
To identify candidate indications for systematic review for their evidence of validity and/or reliability, the type of study design for original research articles (abstract or full text) will be classified using the scheme developed by Oleckno.
