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Following independent validation of this preliminary finding, TLF may be considered as a candidate imaging biomarker that complements traditional liver function classification systems, particularly in cases of discordant findings.
However, from these data, anatomic imaging with CT or MRI, or functional data derived from FDG PET, DW- or DCE-MRI are all candidate imaging modalities to investigate early response predictors.
Candidate imaging biomarkers are the CT-derived calcium score from the coronary arteries [22] or more peripherally located arteries, US-derived intima-media thickness, US- or MRI-derived pulse wave velocity [23], or MRI-based plaque composition [24].
The observation that neuronal network activation is related to the formal neuropsychological testing performance makes fMRI a candidate imaging biomarker for cSLE-associated NCD.
Future research should focus on the identification of optimal combinations of candidate imaging targets, and dedicated studies are needed to assess the accuracy of such combinations to discriminate between breast cancer (subtypes) and benign breast lesions and normal tissue.
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Assuming such an agent will be developed and there are several candidates, imaging of prostate cancer will be challenging and will probably require additional improvements in instrumentation.
Because of the bivalency, fast blood clearance, and deep tumor penetration, the panitumumab F ab' 2 fragment is a good candidate for imaging.
Among them, [18F] DPA-714 has been considered as an excellent candidate for imaging neuroinflammation after cerebral ischemia in rodents [3, 24, 33, 34].
Of the six compounds, TASP0410457 (also diminutively called TASP457) and TASP0434988 exhibited fast kinetics and relatively high brain uptakes in ex vivo LC-MS/MS and were selected as candidate PET imaging agents.
Optical coherence tomography (OCT) is a promising candidate for imaging microvasculature in vivo.
CAIX targeted Zr-PET imaging is a candidate for imaging hypoxia in different types of tumors and deserves further exploration.
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