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Genetic programming (GP) can learn complex concepts by searching for the target concept through evolution of a population of candidate hypothesis programs.
Such a gene subset provides a reasonable "epistatic" candidate hypothesis for a genetic association study that explore links between genotype and phenotype, e.g. for human disease.
(A ) Three models were evaluated, each showing a candidate hypothesis for the three-way association between genotype (G), expression (E) and trait (T).
Lead is known to disrupt dopaminergic function in experimental studies and can induce oxidative stress (Ercal et al. 2001), which is a candidate hypothesis for the etiology of PD (Jenner 2003).
CTLP generation through breakage-fusion-bridge cycles would be a viable candidate hypothesis compatible both with the statistically significant telomere enrichment and the high proportion of arm-level pulverization.
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For the hypothesis layer, multiple candidate hypotheses with different change-points are considered.
Or, conversely, it discards candidate hypotheses that render the sample too improbable.
Over-fitting is not a problem for IVSA because it does not generate over-fitted candidate hypotheses during the learning.
By contrast, an option is forced (rather than avoidable) just in case the candidate hypotheses are both mutually exclusive and exhaustive of the possibilities.
Notice that the pattern of classical statistics resembles that of eliminative induction: in view of the data we discard some of the candidate hypotheses.
Carefully picking his words, he tells FORBES: "There are some candidate hypotheses that there may be general laws for things like biospheres and econospheres".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com