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Unexpected selectivity issues versus tissue plasminogen activator in the former series were addressed in the later, delivering a robust candidate for progression towards clinical studies.
However, such studies do not necessarily lead to identification of the optimal human therapeutic candidate for progression into clinical trials.
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They are no longer considered as committed to their work in the same way and so not serious candidates for progression.
Lately, interest in this area has increased with the identification of new candidate biomarkers for progression.
This could then be potentially used to identify candidate biomarkers for progression of disease from steatosis to steatohepatitis to fibrosis.
These predictions may be used to select candidate antibodies for progression to in vivo evaluation and to assess the potential value of affinity enhancement.
An additional consideration relating to the use of in vitro assays to select candidate antibodies for progression is that they fail to account for antibody properties which may influence tumour penetration in vivo.
In human breast cancer, the interaction of tumour cells with the ECM via CD44 is favoured as a major candidate for tumour progression and metastasis.
A hormone such as prolactin, whose normal action is to promote cell proliferation and differentiation, was soon identified as a potential candidate for the progression of breast cancer, where cells are proliferating and surviving inappropriately (Clevenger et al, 2003).
These unique features make lentiviral vectors attractive candidates for further progression into CF gene therapy trials.
In this work, using our new method, we identified the MR candidates for diabetes progression, 5 TFs and their regulated genes, in GK rats.
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