Coding sequences of the 18 RXLR candidate effectors were deduced from seven Hpa isolates.
The majority of the 18 RXLR candidate effectors identified in our study were Hpa-specific (Table 1).
The pathways in which these molecules act should thus be considered as additional candidate effectors of ept mutations.
The changes in tyrosine phosphorylation on proteins involved in metabolism highlight candidate effectors that may contribute to altered metabolism in CSF1-1R-driven phenotypes.
Previous studies aimed at identifying Hpa pathogenicity genes by isolating pathogen transcripts expressed during infection have so far resulted in the isolation of only a few candidate effectors.
Based on such analysis transcription factors were identified as candidate effectors of malignant transformation which may function in the switch from EGF over expression to the malignant state.
Therefore, we reasoned that the Royal family – consisting of known and candidate effectors modules, is a promising group of domains to screen on the arrays.
Of the 13 RXLR candidate effectors with at least two different protein variants, we defined the percentage of variable sites within the protein sequences (Fig. 6).
Two candidate effectors (ClCE2 and ClCE9) showed conidia-specific expression.
Two candidate effectors, PcRXLR15 and PcRXLR59, contain 5 WY-domains.
Only three candidate effectors had detectable homologs with putative functions.
