Sentence examples for candidate drivers from inspiring English sources

Using a hierarchical linear regression algorithm to score our screen results and integrate them with accompanying detailed genetic and proteomic information, we identify vulnerabilities in breast cancer, including candidate "drivers," and reveal general functional genomic properties of cancer cells.

In contrast to a purely frequency based approach to identifying cancer signals and candidate drivers, we and others [11] have proposed a network-based approach to the problem.

It also identifies new candidate drivers, including AGAP2/CENTG1, a putative oncogene and an activator of the PI3K pathway, and three new modules of potential interest.

We also identify new candidate drivers in GBM, including AGAP2/CENTG1, a putative oncogene and an activator of the PI3K pathway; and, three additional significantly altered modules, including one involved in microtubule organization.

This will provide much higher resolution, and a much broader coverage of genes, both of which will enable us to more effectively perform higher confidence network analysis and identify new candidate drivers and modules.

Candidate drivers of potentially irreversible ecological shifts in human-modified landscapes include changes in (1) the total amount and configuration of native vegetation cover through its effects on landscape connectivity, (2) vegetation structure through its influence on natural disturbance regimes, and (3) species composition and the potential for ecological cascades [12].

In parallel, genetic studies in other species have revealed candidate driver genes and their roles in the genesis of osteosarcoma.

We performed integrated network analysis to identify frequently altered network modules and candidate driver mutations in glioblastoma.

BCA2 and PIAS3 that mapped at the maximal amplitude of the BL 41 amplicon are thus candidate driver genes in this amplicon.

In our case, network module analysis identifies new candidate driver genes within previously identified p53/RB and PI3K signaling modules, and within newly identified modules in glioblastoma.

YAP1, BIRC2 and MMP7 genes present in this region were proposed as the candidate driver genes based on their role in apoptosis, cell adhesion and migration; BIRC3 was also mentioned, but not identified as a driver gene.