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In the case of VB1VB, only three candidate complexes (namely models #17, #21 and #36 in FTDOCK ranking) show the Vβ domain located over the central and C-terminal portions of the peptide.
Next, we search for subgraphs to identify candidate complexes.
MAXCOM takes several steps to prioritize all candidate complexes to a query disease.
The ouput of PatchDock is a list of candidate complexes between receptor and ligand molecule.
For all candidate complexes, the MIFs are then calculated and ranked.
MAXCOM then prioritizes all candidate complexes by ranking the MIFs of them.
Similar(36)
In Fig. 15a, the candidate complex mobile network number with the increase of K did not change, but in Fig. 15b, the number of candidates with the increase of location also increased gradually.
Any source interaction not classified as candidate biochemical reaction is considered for assignment to the candidate complex categories.
All source interactions not falling into candidate biochemical reaction or candidate complex categories are considered ordinary binary physical interactions.
This assumption ignores possible dependencies between bait prey associations, but allows computing candidate complex scores in an efficient manner.
The MIF is served to measure the value of functional relationship between a query disease and a candidate complex.
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