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Through this integrative approach, we selected 70 key candidate associations between structural genes and metabolites, and experimentally validated eight novel associations, two of them showing differential genetic regulation in the two environments studied.
Assessment of PPI-genetic disorder candidate associations.
Genes with high association scores are considered as candidate associations.
These results, which are for candidate associations, are supported by clinical knowledge.
In total FACTS provided 27% of all and 36% of informative disease candidate associations.
Approximately half of these associations were previously reported and half were novel candidate associations.
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However, a major limitation is that a large number of candidate association rules are generated, with many antecedent and/or consequent conditions.
In addition, an in silico search using TESS (http://www.cbil.upenn.edu/tess/) failed to identify any candidate association sites for CTCF.
Many candidate association studies for ADHD have been conducted.
One approach to delineating 'causative' genes involves analyzing candidates with neurobiological plausibility in relationship to known characteristics of the disease, termed 'functional candidate association studies' (1).
However, the study of candidate association works well when using a set of known functional candidate genes, which have a clear biological relationship to the disease [ 6].
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