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To allow direct comparison of tumor to non-cancerous expression values, new gene expression ratios (R) were generated from tumor tissue ratio (T/U) and corresponding adjacent non-cancerous tissue ratios (N/U) such that R = log2(T/ U) - log2(N/ U) [ 2].
Zlobec demonstrated that cancerous CD168 expression was a strong prognostic marker in combination with p21 expression [ 18] or CD8-positive lymphocytic infiltration [ 19].
Cancerous CD168 expression is correlated with aggressive biological features in several cancers.
These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.
In conclusion, cancerous CD168 expression can be used as a prognostic marker for gastric cancer owing to its interaction with HA.
Thus, cancerous BMP7 expression in a biopsy may be informative to predict lymphatic invasion.
Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%).
Cancerous CD168 expression may reflect integration of biological behavior from hormonal and cell-cycle molecular conditions.
In contrast, Kwak et al. reported that cancerous BMP7 expression correlated with better surgical outcome in renal cell carcinoma.
Both of these genes separate the normal and cancerous mRNA expression signals in all 24 pairs studied.
In the current study, we did not detect a significant correlation between tumor histology and cancerous CD168 expression.
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