Exact(4)
We demonstrated that FOXA1 expression also has an important role as breast cancer predictor of good outcome in ER-negative breast carcinomas.
In conclusion, our results confirmed the strong association between ERα and FOXA1 in breast cancer and confirmed the role of FOXA1 as a significant breast cancer predictor of good outcome in univariate analysis, directly associated with luminal A and inversely associated with basal-like subtype of breast cancer.
Our goal was to provide a transparent example of the manner in which a genomics-based cancer predictor might be developed from training data and evaluated on independent test data with sufficient detail and documentation to allow the full process to be replicated by other researchers.
GATA3, a transcriptional activator involved in the differentiation of luminal epithelial cells such as MCF-7 and that has been suggested as a breast cancer predictor, displays an inverse correlation to metastasis capability and strong association with estrogen receptors, though it does not appear to be involved in the estradiol signaling pathway [ 30].
Similar(56)
They expressed concerns about the science behind genetic cancer predictors developed by two Duke researchers, oncologist Anil Potti and Nevins.
Simulations of normal tissue contamination caused misclassification of tumors in all predictors evaluated, but different breast cancer predictors showed different types of vulnerability to normal tissue bias.
For participants with cancer, predictors of not working at 12 months included: being older, lower BMI and lower physical well-being.
Mounting albeit still limited evidence from epidemiological studies suggests that breast cancer predictors vary by histological type and hormone receptor status.
A similar approach was taken for the pCR (n = 50, 70,..., 210) and "pCR in ER-negative cancer" predictors (n = 25, 40,..., 85).
After adjustment of known breast cancer predictors and other associated risk factors, the inverse association of somatotype at age seven years with breast cancer remained highly significant (Table 2; OR comparing large to lean somatotype at age seven years = 0.73, 95% CI = 0.58 to 0.91, P trend = 0.004).
AOL is an established on-line breast cancer survival predictor; it calculates a 10-year survival probability based on the patient's age, tumor size, tumor grade, oestrogen-receptor status, and nodal status.
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