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Defects in this conserved BRCA1-dependent RNAPII cleavage and degradation pathway may be critical for the initiation of breast or ovarian cancer, predicting that genetic defects in other conserved components of this pathway may also contribute to these diseases.
Clinical application of this information yielded one of the earliest molecular classification schemata in cancer, predicting the course of disease based on the identity of the sCNA [ 9].
Recent studies in animal models have shown that mutant mice deficient in MMP8 are more susceptible to develop skin cancer, predicting that MMP8 has a protective function against tumor developments [ 29, 30].
They have applied this approach to multiple aspects of oncology: monitoring patients who received cancer vaccines, investigating immunological mechanisms of antigen recognition in cancer, predicting therapeutic efficacy, and correlating immune complexity to patient outcomes.
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Microsatellite instability in colorectal cancer predicts favorable outcomes.
Expression of the oestrogen receptor (ER) in breast cancer predicts benefit from endocrine therapy.
High expression of HOTAIR in diffuse-type gastric cancer predicted poor DFS.
The world is changing, with cancer predicted to be the leading cause of death through to 2030.
Many studies have shown that CTCs in early breast cancer predict recurrence within the first 5 years after diagnosis [ 44- 47].
Abraham et al. [ 34] reported that overexpression of miR-183 in medullary thyroid cancer predicted lymph node metastasis.
The detection of circulating tumor cells (CTCs) in peripheral blood (PB) of patients with breast cancer predicts poor clinical outcome.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com