Exact(8)
Nearly 10 years after an expert panel convened by the National Institutes of Health declared breast-conserving surgery the preferred treatment for most women with early-stage cancer, on average about half of those eligible for the procedure continue to undergo full mastectomies, according to the National Cancer Institute.
Endometrial cancer nearly always develops before colon cancer, on average, 11 years before.
In p53 mutation carriers, it was shown in three independent reports that individuals with the G-allele of SNP309 are diagnosed with cancer on average seven to fifteen years earlier than those p53 mutation carriers homozygous for the T-allele (Table 1) [6]-[8].
Thus, cancer, on average, might not be more disabling than other highly prevalent chronic diseases in the elderly.
There were few significant differences between subgroups; men with a CHEK2 mutation were diagnosed with prostate cancer on average 1.4 years younger than non-carriers (67.5 vs 68.9; P=0.003).
The significance does not hold up for DSS; however, patients with high AR ER ratios died from their breast cancer on average 10 months earlier than patients with low ratios.
One of these studies found that patients with HNPCC who carried the GA or AA genotype developed colorectal cancer on average 11 years earlier than those with the wild type (Kong et al, 2000).
Their study of 88 individuals with inherited p53 mutations demonstrated that carriers of this SNP in either its' homozygous or heterozygous form developed cancer on average 7 years before their wildtype counterparts.
Related(1)
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