The same two trinucleotides, 5'-TCA and 5'-TCG, were the most commonly mutated cytosine-containing motifs in two independent breast cancer mutation data sets.
This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.
Recent advances in sequencing technology allow genome-scale approaches to cancer mutation discovery.
In a cognition-based framework, the issues of cancer mutation, clonal lineage, and cell cell fusion can be reappraised.
The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small molecules.
It is promising that the designed biosensors can be applied for detection of prostate cancer mutation in the future.
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers.
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs).
Dyes can cause allergic dermatitis, skin irritation, cancer, mutation, etc. Dyes can be classified as (Mishra and Tripathy 1993): anionic (direct, acid and reactive dyes), cationic (basic dyes) and non-ionic (dispersive dyes).
Here we evaluate the sensitivity of two technologies for cancer mutation detection and the suitability of whole genome amplified DNA as a template for the detection of BRAF-V600 mutations.
In the clinical treatment of prostate cancer, mutation in the androgen receptor (AR) that occurred in patients, often results in drug resistance because the agonist activity of the drug increases while the antagonist activity decreases.
