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Our study shows a low rate of CK7 expression in SBA patients, with the classic CK20+/CK7− colorectal cancer expression pattern observed in only 43% of patients.
This expression pattern was found to be significantly associated with high levels of DJ-1 protein in the nipple discharge of breast cancer patients, suggesting that it was a secretion-related cancer expression pattern.
As for differences in expression according to the pStage of cancer, expression pattern of TLR2 in both NCT and CT was rather high in pStage II and III than in other pStages, but TLR4 expression pattern was in disorder.
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To further examine whether the moesin expression is altered in cervical cancer, the expression pattern of moesin were studied in normal cervix and human cervical cancer tissues by immunohistochemistry. Moesin was found expressed predominantly in the cytoplasm of normal and cancer cells.
In high-grade prostate cancer the expression pattern of fibronectin was patchy and significantly reduced, suggesting either down-regulation of fibronectin secretion or lack of significant organization into a matrix.
Our findings show that there is a "central core of cervical cancer" protein expression pattern, and suggest that 14-3-3ζ 14-3-3ζ 14-3-3ζmise if the cell proliferates or dies.
In breast cancers, the expression pattern of CXCR4 showed a significant correlation with the degree of lymphatic spread but not with hematogenous metastasis.
Based on the functional characteristics and cancer-specific expression pattern of PPP2R2A (B55α) and Cyclin D1, it is evident that both PPP2R2A and the PPP2R2A-/low/Cyclin D1high phenotype deserve further attention to better uncover their possible clinical and biological importance in BC.
To evidence the role of MMP-14 in human cancer dissemination, expression patterns in human cancer specimens was examined by immunohistochemistry (IHC).
To explore the potential role of the Akt-FOXO3a signaling axis as prognostic markers in breast cancer, the expression patterns of FOXO3a and P-Akt were studied using immunohistochemical staining on a panel of breast cancer samples (Table 2).
Analysis of breast cancer patients' expression patterns can already be highly correlated with recurrence risks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com