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mTOR is a key cancer driver and drug target.
Thirdly, we connect modules identified into a pancancer network to identify cancer driver genes.
Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer.
Chen, H. J. et al. A recellularized human colon model identifies cancer driver genes.
Tamborero, D. et al. Comprehensive identification of mutational cancer driver genes across 12 tumor types.
Fischer, K. & Pflugfelder, G. O. Putative breast cancer driver mutations in TBX3 cause impaired transcriptional repression.
These results indicated that the miR-411 could be a cancer driver in lung tumorigenesis.
First, AMARETTO identifies potential cancer driver genes through integration of copy number, DNA methylation and gene expression data.
The oncogenic event associated with the identified complex rearrangement resulted in an amplification of the known cancer driver gene FGFR2.
Shuai, S., Gallinger, S. & Stein, L.D. DriverPower: combined burden and functional impact tests for cancer driver discovery.
Wadi, L. et al. Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks.
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