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Dataset 1 consists of Illumina-genotyped individuals: HapMap, HGDP, and the Swedish breast cancer controls.
There were 885 bladder cancer controls, 803 kidney cancer controls, and 651 pancreatic cancer controls.
There were 842 breast cancer controls, 1205 lung cancer controls, and 1138 colorectal cancer controls.
In Denmark, both colon cancer controls and population controls were recruited in order to evaluate the potential selection bias in the use of cancer controls.
Four population controls and three to four colon cancer controls were recruited for each case.
Huang et al (1999) studied 887 cases and 28 619 non-gastric cancer controls.
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The results in the controls were further replicated in 10.8% of an independent series of 102 non-cancer controls.
We detected TP53 mutations in the cfDNA of 49% SCLC patients and 11.4% of non-cancer controls.
We assessed the presence of TP53 mutations in the cell-free DNA (cfDNA) extracted from the plasma of 51 SCLC cases and 123 non-cancer controls.
Each of these has identified subsets of proteins that are altered in pancreatic cancer compared to non-cancer controls.
Following the modifications, we established a cross-source serum peptide signature for distinguishing stomach cancer patients from non-cancer controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com