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Moreover, a preserved pro-senescent cancer capability might be therapeutically exploitable by novel senescence-inducing strategies that do no longer damage DNA.
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Further research is to be encouraged, employing systems biology-based approaches to identify the altered regulatory circuitry involved in early NSCLC and decipher the web of interconnected genes that confer hallmark cancer capabilities (Hanahan and Weinberg, 2000).
This limits the undesirable side effects, while potentiating the anti-cancer capabilities of the therapy.
The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo.
A tumor's ability to exploit inflammation to its own benefit is strictly related to the second immune hallmark of cancer, the capability to suppress the immune response directly or via the recruitment of suppressor cells [ 104].
Much of this research has focused on developing more effective ways to harness platinum's cancer killing capabilities.
Multitudes of studies stemming back decades have warned of tobacco smoke's cancer inducing capabilities.
This suggests that some participants place too much trust in the cancer detection capabilities of the screening programme.
Hanahan and Weinberg illustrate in their recent article that inflammation and genome instability are the enabling characteristics in the acquisition of core cancer hallmark capabilities, allowing cancer cells to survive, proliferate and disseminate [ 15].
However, the complex interplay between the tumor's immunogenicity, the host's immune response and the cancer cells' capabilities of evading immune response is still a challenging subject of current research.
Professor Bauer, one of the founders of the German Cancer Research Institute DKFZZ) in Heidelberg, in his founding talk for the institute in 1965 claimed that 'the human body has no cancer fighting capabilities'.
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