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Given its essential role in protein regulation, even slight perturbations in UPS activity can substantially impair cellular function.
These factors can substantially impair the image quality and diagnostic accuracy in many disease entities [ 24– 26].
However, in injured lungs IAH can substantially impair oxygenation [ 8, 15] that is probably due to an increase in pulmonary edema [ 8].
This disorder, which can substantially impair quality of life and has also been associated with increased risk of mortality and disability, is thought to decrease with age but it still common among older people living in high-income countries.
In fields such as oncology, where symptoms are common and can substantially impair patients' functioning and quality of life, information about patients' experiences of AEs is essential for multiple stakeholders, including patients, drug developers, regulators, and payers.
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His lawyer, Lynn Armentrout, argued, "The state doesn't have the power to undo or substantially impair a private contract".
"Confining the president's authority to traditional combat zones thus would substantially impair the ability of the commander in chief to engage and defeat the enemy forces".
The result depicts that high-temperature could substantially impair the collapse strength of a screen/slotted liner.
Corticosteroids substantially impair macrophage killing of Aspergillus spores and mononuclear cell killing of Aspergillus hyphae [ 40].
Local and regional recurrence, metastases and second cancer may substantially impair long-term survival.
However, it is clearly shown that DHS can significantly be related to substantially impaired oral health-related quality of life [ 7– 9].
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