Cyclic voltammetry will not give any information on product formation and direct EC-MS analysis can be strongly hampered by ion suppression effects as well as by unwanted up front fragmentation.
It is addressed that amplification methods usually bring bias, which may strongly hamper the following interpretation of the results.
Although primary culturing of M. ulcerans can provide a definitive BU diagnosis, the value of this method for primary diagnosis is strongly hampered by the fact that colonies take two to three months to appear and even under optimal conditions the sensitivity of the method is limited [ 5, 6].
This coupled with change in climatic condition were strongly hampering our economic income and livelihood activity".
Nevertheless, uncertainty associated with well data (including water flowrates and salinities) strongly hampers the process design task.
This strongly hampers accurate analysis and reproducibility.
However, the effectiveness of radio- and chemotherapy is strongly hampered by tumor cell resistance.
This situation strongly hampers the selection of the most suitable analogues for further clinical validation.
Yet, the subsequent starvation-induced processing of mPho8 into sPho8 is strongly hampered in ESCRT mutants.
Success of cancer vaccination is strongly hampered by immune suppression in the tumor microenvironment (TME).
Without clear standards the evidence-based selection of measurement instruments is strongly hampered.
