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Most of all, however, Assad can simply no longer afford to ignore the growing threat of Isis now that it has started attacking his own forces.
In the United States, you can simply no longer justify the economic costs and lost productivity of traveling short distances by air".
Tell it to the judge, for in order to compensate for the injuries that have reduced Hardaway to offensive caretaker, the Heat can simply no longer afford Mourning battling Ewing to a draw.
As size, complexity and numbers of interconnections grow, so do the vulnerabilities of the system as a whole - which can simply no longer be addressed by the industry's traditional reactive methods.
The powerbrokers of football have decided that the idea of a replay – like the one in which Ronnie Radford dredged up the dreadnought shot from the muddy field of Edgar Street, Hereford, to knock out Newcastle United – can simply no longer be accommodated.
"It's possible these households have already pared back their cover as premiums have risen in recent years but this latest increase may be the tipping point that means they can simply no longer afford it," said an iSelect spokeswoman, Laura Crowden.
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If they are located exactly where a city needs to grow, they can simply decide "no".
The New Democracy candidate will be Antonis Samaris, who has spent the last year arguing that Greece can simply say no to Europe's austerity demands without any negative consequences.
Ashe, for his part, believes that it is a law of sport that everything that happens affects everything that happens thereafter, and that Graebner can simply have no idea what patterns might have followed if he had won the debated point.
At the moment, the man can simply do no right.
They can simply say NO to the spraying of chemicals that undermine our health, poison our food, and impact the well-being of our children in so many ways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com