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"can significantly reduce" is correct and usable in written English.
You can use it to describe a change or decrease in something. For example, "Implementing eco-friendly practices can significantly reduce carbon emissions."
Exact(60)
They can significantly reduce pain and improve a patient's wellbeing.
Smaller Mg nanoparticles can significantly reduce κ.
This can significantly reduce eligibility for need-based financial aid.
"By adding fixed income to that, we can significantly reduce the probability of loss".
The agency also believes that prevention can significantly reduce the number of cases.
A year shaved off an estimate, or a decimal point's difference can significantly reduce pension obligations.
"With a bit of forward planning, we can significantly reduce the cost of a day out.
Just two fish meals a week can significantly reduce the chance of having a heart attack.
Both analogues can significantly reduce the corticosteroid suppression in vivo.
The components can significantly reduce time and material waste.
A healthy lifestyle can significantly reduce this risk.
More suggestions(16)
can significantly slash
can noticeably reduce
can vastly reduce
can drastically reduce
can dramatically reduce
can markedly reduce
can significantly decreased
can significantly limit
can significantly hurt
can significantly outstrip
can significantly impact
can significantly alter
can significantly enhance
can significantly disrupt
can significantly boost
can significantly help
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com