CDDP is widely used to treat solid tumors in clinical therapy, although drug resistance can severely limit the effects of many chemotherapy drugs.
Lefebvre et al. (1973) showed that neglecting the end effect can severely affect the factor of safety results especially in narrow slopes with slope surface angles steeper than 20°.
Thus, individuals diagnosed with T1DM must rely on insulin injections, a therapy of incomplete efficacy that comes with an impaired quality of life, and serious long-term side effects, that can severely limit life expectancy.
In complex systems, inappropriate inferences based on potential outcomes can severely distort the interpretation of effects and misdirect the application of interventions (Eisenberg et al. 2003; Halloran and Struchiner 1995; Jacquez et al. 1994).
All of these factors have profound effects on patient safety, and can severely impact an institution's HCAHPS Hospital Consumer Assessment of Healthcare Providerss and Systems) scores, thereby effecting its bottom line.
This is important to consider when the effects of treatment can severely damage a patient's quality of life.
At the microscopic level, folding stability of essential proteins and the toxic effects of misfolding can severely limit genome size under high mutation rates (Zeldovich et al. 2007; Chen and Shakhnovich 2009), providing an explanation for differences in proteome stability distributions of viruses and bacteria (Chen and Shakhnovich 2010).
In addition, there are rather acute effects of treatment that can severely affect a child's quality of life, and among these can be treatment-induced loss of hearing, fatigue and weakness, increased susceptibility to infection, and growth retardation.
Cosmic rays lead to a plethora of radiation effects including Single Event Transients which can severely degrade microelectronic functionality.
GalN/LPS treatment can severely disturb substance metabolism in the liver, with different effects on metabolites compared with those observed in the plasma.
