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Although the magnitude of AGAT inactivation and the temporal nature of its regeneration following treatment with temozolomide on its approved schedule, 150 200 mg m−2 day−1 for 5 days every 4 weeks, have not been studied, it can reasonably be speculated that partial or complete AGAT regeneration would likely occur in the relatively long 23-day interval between each 5-day course of temozolomide.
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Considering the relatively high latent TB prevalence, it could reasonably be speculated that active TB in this subpopulation would also be high.
The imprecise tmax can reasonably be attributed to infrequent sampling.
This reduction can reasonably be considered clinically relevant.
About the reasons can only be speculated.
However, the method of introduction can only be speculated upon.
"The only thing we can do is speculate," he says.
All we can do is speculate.
All I can do is speculate.
It was speculated that it was reasonably possible to create an engine with up to 25% gain in efficiency over the Rolls-Royce/Snecma Olympus 593.
Although not formally proven by ad hoc studies, it can be reasonably speculated that the same could apply also for other SSRIs, being mainly metabolized not only by CYP2D6 but also by CYP2C19, CYP3A, and CYP1A2 which in turn are encoded by highly polymorphic genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com